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You may have heard Ozpik and WiggsBut did you know that they have become so popular that there are problems with the supply of the medication – which is expected to last until the end of 2024?
A big reason for the high demand is that many people use the drug to lose weight quickly and unnecessarily. Although Wegovy has NHS approval for weight management, Ozempic is a prescription medicine designed to Treating type 2 diabetes. As a result, drug shortages mean that patients cannot continue to receive treatment.
In March this year, NHS England announced New vaccines, Monjarowhich can be given to people who can’t get other types of injections, called GLP-1 RA drugs. The new vaccine, also called tezpatide, is considered more effective than the semaglutide drugs Ozempic and Wegovy.
But these drugs aren’t right for everyone and can have serious and dangerous side effects.
How do weight loss injections work?
According to Dr. Mark Vanderpump, he is Welbeck Oneweight loss shots work by mimicking the hormones that maintain normal blood sugar levels.
“More than two decades ago, hormone researchers discovered a hormone called GLP-1 that boosts insulin action and lowers blood sugar levels,” he explained to Metro.co.uk.
“GLP-1 has been found in high amounts in the saliva of a large poisonous lizard found in the Arizona desert that rarely eats. This discovery has allowed scientists to synthesize an analog of GLP-1 that can be injected and last a long time in the body.”
Is Mounjaro more effective than Ozempic and Wegovy?
“Mounjaro (or tirzapatide) is the latest version of the injection, which increases the body’s production of insulin and decreases the amount of glucose produced by the liver, thereby lowering blood sugar.
“By acting on the appetite center of the brain, it creates a feeling of fullness and has been shown to be a very effective weight loss agent,” Dr. Vanderpump says.
However, unlike these other drugs, Mounjaro also mimics another hormone, gastric inhibitory peptide (GIP). This dual target makes Mounjaro more effective than somaglutamine in aiding weight loss.
“One study showed that patients receiving the highest dose (15 mg per week) lost an average of 15-20% of their body weight over 12-18 months, while patients receiving semaglutide lost 10-15% of their body weight,” Dr. Vanderpump added.
Who is eligible to participate in Mounjaro?
“Although the drug is currently approved for the treatment of patients with type 2 diabetes, it has been shown to be a very effective weight loss medication for patients with prediabetes or metabolic syndrome, which is people with genetic markers of insulin resistance who have struggled with weight management throughout their lives,” the doctor said.
However, as people seek to lose weight, demand for injections has surged, meaning that diabetics cannot take their medications. This not only puts treatment plans at risk, but is also harmful to people who do not have metabolic differences.
Dr. Vanderpump stresses that “Mounjaro is not suitable for people who are of normal or slightly above normal weight and want to lose further weight for cosmetic reasons.”
What are the side effects of Mounjaro?
“Common side effects are similar to those of semaglutide and include Feeling unwell And have indigestion, constipate and diarrheaLess common side effects include Gallstones and pancreatitishe explained.
In the long term, these drugs are more effective than statins for Heart Health Diabetic patients. However, research on the cardiovascular benefits of Mounjaro is still ongoing.
Although the main side effects of these drugs are Weight loss‘Any weight lost is likely to be regained within two years of stopping the drug,’ Dr. Vanderpump noted.
That’s why these vaccines, no matter how they look, No panaceaInstead, they may be best viewed as a supporting tool to help people with a condition embark on their journey to better health while making lifestyle changes such as eating healthier and getting more exercise.
Mounjaro Side Effects – At a Glance
short term:
- Nausea and vomiting
- Indigestion and heartburn
- constipate
- diarrhea
- Headache
- Injection site reactions (redness, bruising, tenderness, swelling)
- Gallstones and pancreatitis (rare)
- Positive effects on heart health (in some cases)
long:
- Weight loss
- Loss of muscle mass
- Slower metabolism
- Insulin resistance
“Patients receiving tirzepatide (Mounjaro) or semaglutide (Ozempic/Wegovy) often describe their Relationship with food It makes their lifestyle efforts pay off,” he said.
But for others, illnesses and other side effects from these vaccines can make lifestyle changes more difficult, meaning people are less able to take better care of their health once they stop taking the medication.
People also worry about how weight loss occurs. Research Studies have shown that about 40% of the weight people lose after using Wegovy is muscle mass, which is a very important part of the human body structure and can regulate metabolism after stopping the drug. Mounjaro is also believed to have the same effect.
“Basal metabolic rate (BMR) refers to the number of calories your body burns while performing daily life-sustaining activities. BMR is primarily determined by your total lean muscle mass, as lean muscle mass requires a lot of energy to maintain. Having more muscle requires more energy to function and improves metabolism,” explains personal trainer Sarah Campus.
According to physical therapists and nutritionists Eleanor Heaton-ArmstrongIn the long term, people with metabolic problems are worse off because they lose muscle mass.’ Loss of muscle mass This can certainly cause concern for anyone, but it is also highly advised against for those trying to regulate their metabolism or monitor insulin levels.
“People with type 2 diabetes or prediabetes should try to avoid muscle loss because it can adversely affect their metabolic rate. Insulin resistance It is directly related to lipid accumulation, which leads to metabolic defects, which is a vicious cycle.
“Losing weight can be helpful in managing and preventing type 2 diabetes, but the cost of losing weight with these vaccines is not always worth it.”
These Vaccines don’t work for everyone‘It is also important to remember that up to 10-15% of people do not lose weight or cannot tolerate the medication. And Not safe during pregnancyso it needs to be stopped six weeks before pregnancy. It is not clear whether it is safe during breastfeeding,” adds Dr. Vanderpump.
Can you get Mounjaro on the NHS?
Mounjaro is available in the UK for the treatment of type 2 diabetes.
“It is usually only prescribed when other medications have proven ineffective in treating diabetes, or when there are side effects or other medical conditions.”
“The drug is specifically for people with diabetes who have a body mass index (BMI) of over 35. It is not suitable for non-diabetic obese people or those with pre-diabetes, however, those who cannot access it through the NHS can get it on private prescription, which currently costs around £150 a month,” said Dr Vanderpump.
But before trying to get a prescription for Mounjaro, it’s important to consider whether it’s right for you.
“For people who don’t have disease, these drugs can cause strong interference with the body’s natural processes and reduce quality of life,” Heaton-Armstrong warned.
“Even for people with diabetes, the risks are significant unless they are closely monitored by a healthcare professional. Losing weight while maintaining muscle mass is not easy and usually requires a more or less complete change in one’s diet and exercise habits, which is difficult even without the additional complications of diabetes and medications.”
Education, access to healthy foods, regular exercise, and building and maintaining muscle mass are all vital and need to be considered in conjunction with Mounjaro.
Do you have a story to share?
Contact by Email MetroLifestyleTeam@Metro.co.uk.
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