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Made from hyaluronic acid.
Researchers have developed a method for treating spinal cord injuries in animals that has shown promising results, particularly in improving motor performance during the recovery period, reports Interesting Engineering.
More specifically, the researchers developed a novel dopamine-linked hyaluronic acid (HADA) hydrogel and an engineered peptide called HGF-(RADA)4-DGDRGDS (HRR) to promote tissue integrity after spinal cord injury.
The researchers showed that the hydrogel improved nerve regeneration after spinal cord injury in animals, according to a statement from the American Association for the Advancement of Science.
The study authors wrote: “This strategy has multiple applications in treating central nervous system injuries and other diseases. The gel transforms dense scar tissue into a suitable environment that promotes the infiltration of regenerative cells to support neural therapy.”
However, the researchers note that certain biological substances can help create a more suitable environment for nerve repair and regeneration at the site of injury. They believe that the dense tissue produced in this case is not a suitable medium for the regeneration of nerve axons. Implanting specific biomaterials may be a way to promote the regeneration of axons in spinal cord scars.
This study showed that curcumin and neurotrophin 3 (NT-3) enhanced hydrogels with dopamine-linked hyaluronic acid (HADA) and designer peptides (HRR). Since NT-3 is an element that promotes nerve growth, it can greatly improve motor, sensory and bladder function in mice and motor function in canines by promoting nerve regeneration. In addition, the hydrogel transformed scar tissue into a favorable environment for axon growth.
The study authors say the hydrogels alter the infiltration rate of PDGFRβ+ cells in a parallel pattern, transforming dense scars into aligned fiber beds that guide axon regeneration and produce changes.
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