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While the study does not definitively establish cause and effect, it does point to a potential link between breast, ovarian, skin and uterine cancers and increased patient exposure to endocrine-disrupting chemicals such as permanent or pre-polyfluoroalkyl substances (PFAS) and phenols, it shows.
The study highlighted a striking pattern among women; those with higher exposure to these compounds (a combination of pre-PFAS and long-chain PFDEs) were twice as likely to develop melanoma. Likewise, those with higher exposure to perfluoronanoacids (PFNAs) and perfluorooctanoic acid (PFUA) were almost twice as likely to have previously been diagnosed with melanoma.
The study also identified an association between PFOA exposure and early diagnosis of uterine cancer.
Additionally, women with higher exposure to phenols, including bisphenol and 2,5-dichlorophenol, were more likely to have ovarian cancer diagnosed at an early stage.
The study, conducted by researchers at the University of California, San Francisco (UCSF), the University of Southern California (USC) and the University of Michigan, examined data from more than 10,000 people as part of a project funded by the National Institutes of Health.
They evaluated the relationship between phenol, PFC exposure, and prior cancer diagnosis, focusing on potential differences by race and ethnicity.
PFA has entered the environment through products such as PTFE containers, waterproof clothing and food packaging. They remain in the environment and the human body for a long time.
The findings suggest that these chemicals may disrupt the function of female hormones and may contribute to the development of hormone-related cancers.
Additionally, the researchers advocate that the U.S. Environmental Protection Agency (EPA) permanently regulate these chemicals as part of a list of chemicals to prevent exposure and protect public health.
Overall, the results of this study reveal a complex interaction between chemical exposure and cancer risk in women. Although a cause-effect relationship has not been conclusively established, there is evidence that high levels of endocrine-disrupting chemicals, such as permanent chemicals and phenols, are strongly associated with the incidence of breast, ovarian, skin, and uterine cancers.
The increased risk of melanoma and uterine cancer in women is alarming, as is long-term exposure to the chemicals, which increases a woman’s risk of ovarian cancer.
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