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Researchers at the University of Birmingham have discovered that PEPITEM, a naturally occurring peptide (small protein), could be used to treat osteoporosis and other bone loss diseases.
how it is communicated visti.az With reference to TASS news agency, the scientists shared the results of their work in the journal Cell Reporting Medicine.
PEPITEM (Peptide Inhibitor of Transendothelial Migration) was first discovered in 2015 by scientists at the University of Birmingham. It is produced and found in low concentrations in everyone’s body.
In a new study, it became clear that increasing its concentration stimulates an increase in mineral density in young bone structures that are not in a pre-osteoporotic state. PEPITEM also has the ability to influence the natural process of bone repair that is disrupted by aging or inflammatory disease.
Experiments on aged mice show that PEPITEM supplementation limits bone loss and increases bone density. This is particularly important in osteoporosis, a metabolic bone disease characterized by reduced bone density due to a loss of bone mass. Studies have also found that the peptide can prevent the erosion of cartilage and bone tissue during arthritis in animals.
These results were corroborated by other studies using human bone tissue harvested from elderly volunteers during joint surgery. Bone cells in older adults respond positively to PEPITEM, as evidenced by accelerated maturation of osteoblasts (bone stem cells) and an increased ability to generate and mineralize bone tissue.
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