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Acne is a skin disease According to the Mayo Clinic, this happens when hair follicles become clogged with oil and dead skin cells. As a result, they can cause pimples, whiteheads, and blackheads on the face, back, chest, and other parts of the body.
Treatments include retinoids, antibiotics, and other medications. However, these can cause side effects such as redness, sun sensitivity, and elimination of beneficial bacteria.
To avoid other changes in the skin, a research team from Pompeu Fabra University in Barcelona conducted a study Major discovery of a radical approach to acne treatment.
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Nastassia Knödlseder, a synthetic biologist and leader of the research team, revealed that by using Proteobacterium acnes (a common bacterium in acne) and modifying its genes, it can secrete a Molecules that reduce sebum accumulation in the skin.
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According to the University Clinic of Navarra, sebum is a fatty or oily substance produced by the sebaceous glands in the skin, and although its function is to moisturize, insufficient production can lead to adverse skin conditions, Like acne.
Therefore, in order to effectively and safely treat this skin disease, the researchers developed a strategy to modify P. acnes to produce a protein called NGAL, which tells the cells that produce the oily substance to reduce their activity, following the mechanism of action of a drug called isotretinoin, which treats severe acne.
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acne.
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During the research, different experiments were conducted in laboratory cultures and mice, which showed promising results because Modified acne bacteria can reduce sebum levels and were found in hair follicles but did not cause additional inflammation.
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This approach represents a great A Breakthrough in Acne Treatmentbut human clinical studies are still needed to fully evaluate efficacy and safety. Although studies in cell culture and animal models are encouraging, human skin has significant differences.
So, while there are still some challenges ahead, genetic modification of bacteria for acne treatment marks a radical change in medicine and dermatology.
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