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The drug ubrogepant may be effective in helping people tolerate migraines without symptoms when used at the first sign of a migraine, before the headache begins, according to a new study published in the journal Migraine. Neurologythe medical journal of the American Academy of Neurology.
They studied people with migraines who were able to recognize when a migraine was about to start because they had early symptoms, such as sensitivity to light or sound, feeling tired, neck pain, stiffness, or dizziness, write Eureka Alert!
Ubrogepant is a calcitonin gene-related peptide receptor antagonist, or CGRP inhibitor. CGRP is a protein that plays a key role in the migraine process.
– Migraine is one of the most common disorders in the world, but many people with it do not receive treatment or are dissatisfied with the treatment they receive. The key may be to treat migraine at the first sign of a headache, even before it occurs. Our study is encouraging, showing that ubrogepant can help people with migraines regain normal function – said Richard B. Lipton, M.D., a researcher at Albert Einstein College of Medicine in the Bronx and a member of the American Academy of Neurology.
The study involved 518 people who suffered at least one migraine per year. All participants had early symptoms that indicated a migraine was about to begin.
All participants were divided into two groups. The first group took a placebo at the first migraine attack and 100 mg of ubrogepant at the second migraine attack. The second group took ubrogepant first and a placebo the second time.
The day after taking the drug or pill, 65% of people taking ubrogepant felt better, compared with 48% of those taking the placebo.
“Considering our findings, treatment with ubrogepant could help people with early migraine symptoms to prevent migraine attacks at their earliest stages and continue to function normally. This would significantly improve their quality of life,” Lipton said.
(Telegram Nauka/EurekAlert!)
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